Structure via PubChem · Public domain (PubChem)
igmesine
Sign in to saveIgmesine (JO-1,784) is a sigma receptor agonist (IC50 = 39 nM (rat brain)). It has neuroprotective and antidepressant-like effects in animal studies, as well as nootropic effects in models of age-related cognitive decline. In two phase II clinical trials, igmesine was found to be effective in the treatment of depression and was as active as the comparator fluoxetine. However, in a large phase III clinical trial, igmesine failed to show significant effectiveness for depression. The drug has not been developed further. ==References==
In the Vinony graph
Vinony's link graph records 177 inbound references to igmesine, and connects out to depression, cocaine and digital object identifier.
Vinony files it under Alkene derivatives, Amines and Chemical pages without DrugBank identifier.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C23H29N
- Molecular weight
- 319.5 g/mol
- IUPAC name
- (E)-N-(cyclopropylmethyl)-N-methyl-3,6-diphenylhex-5-en-3-amine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 319.23
Show 3 more facts
- chemical formula
- C₂₃H₂₉N
- isomeric SMILES
- CCC(C/C=C/C1=CC=CC=C1)(C2=CC=CC=C2)N(C)CC3CC3
- canonical SMILES
- CCC(CC=CC1=CC=CC=C1)(C2=CC=CC=C2)N(C)CC3CC3
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Igmesine (JO-1,784) is a sigma receptor agonist (IC50 = 39 nM (rat brain)). It has neuroprotective and antidepressant-like effects in animal studies, as well as nootropic effects in models of age-related cognitive decline. In two phase II clinical trials, igmesine was found to be effective in the treatment of depression and was as active as the comparator fluoxetine. However, in a large phase III clinical trial, igmesine failed to show significant effectiveness for depression. The drug has not been developed further. ==References==
Category:Amines Category:Alkene derivatives Category:Cyclopropyl compounds Category:Sigma agonists
Excerpted from Wikipedia’s “igmesine” article, available under the CC BY-SA 4.0 licence.