(+)-butaclamol

Butaclamol (AY-23,028) is a type of antipsychotic which was never marketed. Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist. ==Discussion== pKa = 7.15 (uncorrected for ionic strength)

Research

546 papers

Protective Effects of (-)-Butaclamol Against Gentamicin-Induced Ototoxicity: In Vivo and In Vitro Approaches.International journal of molecular sciences · 2025
Butaclamol hydrochloride in newly admitted schizophrenics.Psychopharmacology communications · 1975
Butaclamol in the treatment of schizophrenia. A standard-controlled clinical trial.International pharmacopsychiatry · 1978
Use of the butaclamol template in a search for antipsychotic agents with lessened side effects.Journal of medicinal chemistry · 1979
[Effect of butaclamol enantiomers on hypothalamic tyrosine hydroxylase in the rat brain].Biulleten' eksperimental'noi biologii i meditsiny · 1984

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Wikidata facts

Mass: 361.240565

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chemical formula: C₂₅H₃₁NO
isomeric SMILES: CC(C)(C)[C@@]1(CCN2C[C@H]3C4=CC=CC=C4CCC5=C3C(=CC=C5)[C@@H]2C1)O
canonical SMILES: CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O
Commons category: Butaclamol

Sources (1)

wikidata.org

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Article

4 sections

Contents

Discussion
Synthesis
See also
References

McN-4171 is an analog of butaclamol. McN-4612-Y is also described in the attached article. This is similar to McN 4612-z except it is the opposite optical antipode. It is therefore supposedly an antipsychotic.