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cloperastine
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Cloperastine (INN) or cloperastin, in the forms of cloperastine hydrochloride (JAN) (brand names Hustazol, Nitossil, Seki) and cloperastine fendizoate, is an antitussive and antihistamine that is marketed as a cough suppressant in Japan, Hong Kong, Brazil and in some European countries. It was first introduced in 1972 in Japan, and then in Italy in 1981.
Chemical data
- Formula
- C20H24ClNO
- Molecular weight
- 329.9 g/mol
- IUPAC name
- 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine
- SMILES
- C1CCN(CC1)CCOC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
- InChIKey
- FLNXBVJLPJNOSI-UHFFFAOYSA-N
- XLogP
- 4.8
- Polar surface area
- 12.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Cough
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 329.155
- Has use
- medication
Show 3 more facts
- chemical formula
- C₂₀H₂₄ClNO
- canonical SMILES
- C1CCN(CC1)CCOC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
- defined daily dose
- 60.0
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Side effects
- Pharmacology
- Synthesis
- See also
- References
Cloperastine (INN) or cloperastin, in the forms of cloperastine hydrochloride (JAN) (brand names Hustazol, Nitossil, Seki) and cloperastine fendizoate, is an antitussive and antihistamine that is marketed as a cough suppressant in Japan, Hong Kong, Brazil and in some European countries. It was first introduced in 1972 in Japan, and then in Italy in 1981.
==Side effects== Adverse effects may include sedation, drowsiness, heartburn, and thickening of bronchial secretions.
Excerpted from Wikipedia’s “cloperastine” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
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