IKZF3

Also known as AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3, IMD84

Zinc finger protein Aiolos, also known as Ikaros family zinc finger protein 3, is a protein encoded in humans by the IKZF3 gene.

Gene data

IKZF3

Name: IKAROS family zinc finger 3
Type: protein-coding
Aliases: AIO, AIOLOS, IMD84, ZNFN1A3

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012].

via MyGene.info