IL24

Name

interleukin 24

Type

protein-coding

Position

206,897,443–206,904,139 (+)

Aliases

C49A, FISP, IL10B, MDA7, MOB5, ST16

Ensembl

ENSG00000162892

RefSeq RNA

NM_001185156.1, NM_001185157.1, NM_001185158.1, NM_006850.3, NM_181339.1

RefSeq protein

NP_001172085.1, NP_001172086.1, NP_001172087.1, NP_006841.1, XP_011507403.1

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

interleukin 24

Symbol

IL24

Biotype

Protein coding

Organism

Homo sapiens

Location

1:206,897,443-206,904,139

Strand

Forward (+)

Assembly

GRCh38