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ProteinQ909381· pop 11· linked from 292 articles

interleukin 21

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Also known as interleukin-21 isoform, IL21, interleukin-21, Za11

mammalian protein found in Homo sapiens

Protein · UniProt

Interleukin-21

Gene
IL21
Organism
Homo sapiens (Human)
Length
162 aa
Molecular mass
18,653 Da
Evidence
1: Evidence at protein level

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-…

3D-structureAlternative splicingCytokineDisease variantDisulfide bondGlycoproteinProteomics identificationReference proteome
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Swiss-Prot (reviewed) · via UniProt

Research

2,427 papers

via PubMed

Clinical Trials

16 registered

via ClinicalTrials.gov

Available in 11 languages

via Wikidata sitelinks · CC0