IL27
Sign in to saveAlso known as IL-27, IL-27A, IL27A, IL27p28, IL30, p28, Interleukin 30, IL-30
protein-coding gene in the species Homo sapiens
Gene data
IL27- Name
- interleukin 27
- Type
- protein-coding
- Position
- 28,499,360–28,512,051 (−)
- Aliases
- IL-27, IL-27A, IL27A, IL27p28, IL30, p28
- Ensembl
- ENSG00000197272
- RefSeq RNA
- NM_145659.3, XM_054379989.1
- RefSeq protein
- NP_663634.2, XP_054235964.1
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interleukin 27
- Symbol
- IL27
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:28,499,360-28,512,051
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 17087
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/246778
- genomic end
- 28523372
- genomic start
- 28510683
- chromosome
- human chromosome 16
- cytogenetic location
- 16p12.1-p11.2
Sources (3)
via Wikidata · CC0