integrin subunit alpha 5

Also known as CD49 antigen-like family member E, fibronectin receptor, alpha polypeptide, integrin alpha-F, VLA-5, integrin, alpha 5 (fibronectin receptor, alpha polypeptide), very late activation protein 5, alpha subunit, fibronectin receptor subunit alpha, integrin alpha-5

mammalian protein found in Homo sapiens

Protein · UniProt

Integrin alpha-5

Gene: ITGA5
Organism: Homo sapiens (Human)
Length: 1,049 aa
Molecular mass: 114,536 Da
Evidence: 1: Evidence at protein level

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cel…

3D-structureCalciumCell adhesionCell junctionCell membraneCleavage on pair of basic residuesDirect protein sequencingDisulfide bond

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Swiss-Prot (reviewed) · via UniProt