interactome
Sign in to saveIn molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein–protein interactions (PPIs); or between small molecules and proteins.) but can also describe sets of indirect interactions among genes (genetic interactions). 400px|right|thumb|Part of the DISC1 interactome with genes represented by text in boxes and interactions noted by lines between the genes. From Hennah and Porteous, 2009. The word "interactome" was originally coined
Article
31 sectionsContents
- Molecular interaction networks
- Size
- Yeast
- Genetic interaction networks
- Interactomics
- Experimental methods to map interactomes
- Computational methods to study interactomes
- Validation
- Predicting PPIs
- Text mining of PPIs
- Protein function prediction
- Perturbations and disease
- Network structure and topology
- Studied interactomes
- Viral interactomes
- Bacterial interactomes
- Eukaryotic interactomes
- Predicted interactomes
- Network properties
- Degree distribution
- Hubs
- Modules
- Evolution
- Criticisms, challenges, and responses
- See also
- References
- Further reading
- External links
- Interactome web servers
- Interactome visualization tools
- Interactome databases
In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein–protein interactions (PPIs); or between small molecules and proteins.) but can also describe sets of indirect interactions among genes (genetic interactions). 400px|right|thumb|Part of the DISC1 interactome with genes represented by text in boxes and interactions noted by lines between the genes. From Hennah and Porteous, 2009. The word "interactome" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq. Mathematically, interactomes are generally displayed as graphs. While interactomes may be described as biological networks, they should not be confused with other networks such as neural networks or food webs.
==Molecular interaction networks== Molecular interactions can occur between molecules belonging to different biochemical families (proteins, nucleic acids, lipids, carbohydrates, etc.) and also within a given family. Whenever such molecules are connected by physical interactions, they form molecular interaction networks that are generally classified by the nature of the compounds involved. Most commonly, interactome refers to protein–protein interaction (PPI network) (PIN) or subsets thereof. For instance, the Sirt-1 protein interactome and Sirt family second order interactome is the network involving Sirt-1 and its directly interacting proteins where as second order interactome illustrates interactions up to second order of neighbors (Neighbors of neighbors). Another extensively studied type of interactome is the protein–DNA interactome, also called a gene-regulatory network, a network formed by transcription factors, chromatin regulatory proteins, and their target genes. Even metabolic networks can be considered as molecular interaction networks: metabolites, i.e. chemical compounds in a cell, are converted into each other by enzymes, which have to bind their substrates physically.