intercellular adhesion molecule 1
Sign in to saveAlso known as epididymis secretory sperm binding protein, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, major group rhinovirus receptor, cell surface glycoprotein P3.58, ICAM1, ICAM-1
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium.
Protein · UniProt
Intercellular adhesion molecule 1
- Gene
- ICAM1
- Organism
- Homo sapiens (Human)
- Length
- 532 aa
- Molecular mass
- 57,825 Da
- Evidence
- 1: Evidence at protein level
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength (PubMed:3086451, PubMed:3340213, PubMed:38195629). Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). During leukocyte trans-endothelial migration, ICAM1 engagement promotes t…
Swiss-Prot (reviewed) · via UniProt
Research
25,591 papers- Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation.Biochimica et biophysica acta. Reviews on cancer · 2024
- Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024
- Islet beta-cells and intercellular adhesion molecule-1 (ICAM-1): Integrating immune responses that influence autoimmunity and graft rejection.Autoimmunity reviews · 2023
- Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States.Journal of cardiac failure · 2023
- High-mannose intercellular adhesion molecule-1 enhances CD16(+) monocyte adhesion to the endothelium.American journal of physiology. Heart and circulatory physiology · 2019
via PubMed
Clinical Trials
28 registered- COMPLETEDAdiponectin, ICAM-1, VCAM-1 Levels and Metabolic Syndrome in Obese AdolescentsUniversitas Airlangga · NCT05685017
- UNKNOWNCellAdhesionMolecule EndometriosisRatio - CAMERAHeinrich Husslein · NCT04294017
- PHASE1COMPLETEDCoxsackie Virus A21 Administered Intravenously (IV) for Solid Tumour Cancers (PSX-X04)Viralytics · NCT00636558
- PHASE1TERMINATEDA Study of the Intratumoural Administration of CAVATAK to Head and Neck Cancer Patients (VLA-X06)Viralytics · NCT00832559
- PHASE1/PHASE2COMPLETEDSubstudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)Merck Sharp & Dohme LLC · NCT04303169
- NACOMPLETEDInflammation, Intracellular Invasion and Colonization of the Nasal Mucosa by Staphylococcus AureusCentre Hospitalier Universitaire de Saint Etienne · NCT04469348
~7 min read
Encyclopedic overview
9 sectionsContents
- Structure
- Function
- Role in cell signaling
- Other functions
- Clinical significance
- Interactions
- References
- Further reading
- External links
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium.
== Structure ==
Excerpted from Wikipedia’s “intercellular adhesion molecule 1” article, available under the CC BY-SA 4.0 licence.