INTS6

Also known as DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6

gen de la especie Homo sapiens

In the Vinony graph

Vinony's link graph records 2 inbound references to INTS6, and connects out to PubMed, human chromosome 13 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 13.

Vinony links it to 7 Wikipedia language editions.

Gene data

INTS6

Name: integrator complex subunit 6
Type: protein-coding
Position: 51,354,077–51,454,264 (−)
Aliases: DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, MRD78, Notchl2
Ensembl: ENSG00000102786
RefSeq RNA: NM_001039937.2, NM_001039938.2, NM_001306091.2, NM_012141.3, XM_011535040.4
RefSeq protein: NP_001035026.1, NP_001035027.1, NP_001293020.1, NP_036273.1, XP_011533342.1

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015].

Gene Ontology

Biological process

snRNA processing snRNA processing regulation of transcription elongation by RNA polymerase II regulation of transcription elongation by RNA polymerase II snRNA 3'-end processing protein localization to chromatin RNA polymerase II transcription initiation surveillance

Molecular function

transmembrane signaling receptor activity protein binding protein-macromolecule adaptor activity protein-macromolecule adaptor activity

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription RNA Polymerase II Transcription Gene expression (Transcription)Gene expression (Transcription)

via MyGene.info

Gene · Ensembl

integrator complex subunit 6

Symbol: INTS6
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:51,354,077-51,454,264
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 8121
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/26512
chromosome: human chromosome 13
genomic start: 51928213
genomic end: 52028400
cytogenetic location: 13q14.3

Sources (3)

via Wikidata · CC0

Article · Español

La subunidad 6 del complejo integrador es una proteína que en humanos está codificada por el gen INTS6 . Las proteínas de caja DEAD, caracterizadas por el motivo conservado Asp-Glu-Ala-Asp (DEAD), son helicasas de ARN putativas. La proteína codificada por este gen es una proteína de caja DEAD que forma parte de un complejo que interactúa con el extremo C de la ARN polimerasa II y participa en el procesamiento del extremo 3 'de los ARNpn. Además, este gen es un supresor de tumores candidato y está ubicado en la región crítica de pérdida de heterocigosidad (LOH). Se han encontrado tres variantes de transcripción que codifican dos isoformas diferentes para este gen.

Abstract from DBpedia / Wikipedia · CC BY-SA