IRS1
Sign in to saveAlso known as HIRS-1, insulin receptor substrate 1
protein-coding gene in the species Homo sapiens
In the Vinony graph
Vinony's link graph records 50 inbound references to IRS1, and connects out to Q180686, Ensembl genome database project and extracellular signal-regulated kinases.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
IRS1- Name
- insulin receptor substrate 1
- Type
- protein-coding
- Position
- 226,731,312–226,799,850 (−)
- Aliases
- HIRS-1
- Ensembl
- ENSG00000169047
- RefSeq RNA
- NM_001445837.1, NM_001445838.1, NM_005544.3, XM_047444223.1, XM_047444224.1
- RefSeq protein
- NP_001432766.1, NP_001432767.1, NP_005535.1, XP_047300179.1, XP_047300180.1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].
Gene Ontology
Biological process
Molecular function
phosphotyrosine residue bindingtransmembrane receptor protein tyrosine kinase adaptor activitytransmembrane receptor protein tyrosine kinase adaptor activitytransmembrane receptor protein tyrosine kinase adaptor activityprotein kinase C bindingsignaling receptor bindinginsulin receptor bindinginsulin receptor binding
Pathways
cGMP-PKG signaling pathway - Homo sapiens (human)FoxO signaling pathway - Homo sapiens (human)Autophagy - animal - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Longevity regulating pathway - multiple species - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
insulin receptor substrate 1
- Symbol
- IRS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:226,731,312-226,799,850
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein IRS1 PDB 1irs.png
Show 5 more facts
- HomoloGene ID
- 4049
- exact match
- identifiers.org/ncbigene/3667
- genomic end
- 226799820
- genomic start
- 226731312
- cytogenetic location
- 2q36.3
via Wikidata · CC0
Connections
Q180686
Entity
Ensembl genome database project
Entity
extracellular signal-regulated kinases
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GRB2
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digital object identifier
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