IRS1
Sign in to saveAlso known as HIRS-1, insulin receptor substrate 1
protein-coding gene in the species Homo sapiens
Gene data
IRS1- Name
- insulin receptor substrate 1
- Type
- protein-coding
- Position
- 226,731,312–226,799,850 (−)
- Aliases
- HIRS-1
- Ensembl
- ENSG00000169047
- RefSeq RNA
- NM_001445837.1, NM_001445838.1, NM_005544.3, XM_047444223.1, XM_047444224.1
- RefSeq protein
- NP_001432766.1, NP_001432767.1, NP_005535.1, XP_047300179.1, XP_047300180.1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].
Gene Ontology
Biological process
Molecular function
phosphotyrosine residue bindingtransmembrane receptor protein tyrosine kinase adaptor activitytransmembrane receptor protein tyrosine kinase adaptor activitytransmembrane receptor protein tyrosine kinase adaptor activityprotein kinase C bindingsignaling receptor bindinginsulin receptor bindinginsulin receptor binding
Pathways
cGMP-PKG signaling pathway - Homo sapiens (human)FoxO signaling pathway - Homo sapiens (human)Autophagy - animal - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Longevity regulating pathway - multiple species - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
insulin receptor substrate 1
- Symbol
- IRS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:226,731,312-226,799,850
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI