KALRN

Also known as ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, kalirin, RhoGEF kinase

Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene. Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1. Is also known to play an important role in nerve growth and axonal development.

Gene data

KALRN

Name: kalirin RhoGEF kinase
Type: protein-coding
Position: 124,033,369–124,726,325 (+)
Aliases: ARHGEF24, CHDS5, DUET, DUO, HAPIP, KALNC2, TRAD
Ensembl: ENSG00000160145
RefSeq RNA: NM_001024660.5, NM_001322988.2, NM_001322989.2, NM_001322990.2, NM_001322991.2
RefSeq protein: NP_001019831.2, NP_001309917.1, NP_001309918.1, NP_001309919.1, NP_001309920.1

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016].