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GeneQ18028212· pop 5· linked from 322 articles

KCNK3

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Also known as K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3, TASK1

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.

Gene data

KCNK3
Name
potassium two pore domain channel subfamily K member 3
Type
protein-coding
Position
26,692,713–26,733,420 (+)
Aliases
DDSA, K2p3.1, OAT1, PPH4, TASK, TASK-1, TASK1, TBAK1
Ensembl
ENSG00000171303
RefSeq RNA
NM_002246.3, XM_005264293.3, XM_054341941.1
RefSeq protein
NP_002237.1, XP_005264350.1, XP_054197916.1

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008].

Gene Ontology

Pathways

Aldosterone synthesis and secretion - Homo sapiens (human)Cortisol synthesis and secretion - Homo sapiens (human)Cushing syndrome - Homo sapiens (human)Neuronal SystemPotassium ChannelsTandem pore domain potassium channelsTWIK-releated acid-sensitive K+ channel (TASK)Muscle contractionPhase 4 - resting membrane potentialCardiac conduction

via MyGene.info

Gene · Ensembl

potassium two pore domain channel subfamily K member 3

Symbol
KCNK3
Biotype
Protein coding
Organism
Homo sapiens
Location
2:26,692,713-26,733,420
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

6 sections
Contents
  • Interactive pathway map
  • Interactions
  • See also
  • References
  • Further reading
  • External links

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.

This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Excerpted from Wikipedia’s “KCNK3” article, available under the CC BY-SA 4.0 licence.

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