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GeneQ18035329· pop 5· linked from 824 articles

KLF2

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Also known as LKLF, Kruppel-like factor 2, Kruppel like factor 2

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

Gene data

KLF2
Name
KLF transcription factor 2
Type
protein-coding
Position
16,324,613–16,328,685 (+)
Aliases
LKLF
Ensembl
ENSG00000127528
RefSeq RNA
NM_006075.1, NM_016198.1, NM_016270.4
RefSeq protein
NP_057354.1

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017].

Gene Ontology

Pathways

FoxO signaling pathway - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Fluid shear stress and atherosclerosis - Homo sapiens (human)EV release from cardiac cells and their functional effectsWhite fat cell differentiationTranscriptional cascade regulating adipogenesisIL-18 signaling pathway

via MyGene.info

Gene · Ensembl

KLF transcription factor 2

Symbol
KLF2
Biotype
Protein coding
Organism
Homo sapiens
Location
19:16,324,613-16,328,685
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~9 min read

Encyclopedic overview

13 sections
Contents
  • Discovery
  • Structure
  • Gene expression
  • Mouse knockout
  • Function
  • Lung development
  • Embryonic erythropoiesis
  • Endothelial physiology
  • T-cell differentiation
  • Adipogenesis
  • See also
  • References
  • External links

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

== Discovery ==

Excerpted from Wikipedia’s “KLF2” article, available under the CC BY-SA 4.0 licence.

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