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GeneQ17853730· pop 7· linked from 818 articles

KLF5

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Also known as BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

In the Vinony graph

Within Vinony's link graph, KLF5 is referenced by 818 other articles, and connects out to PubMed, human chromosome 13 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 13 and Transcription factors.

Its subject is documented across 7 Wikipedia language editions.

Gene data

KLF5

Name: KLF transcription factor 5
Type: protein-coding
Position: 73,054,976–73,077,586 (+)
Aliases: BTEB2, CKLF, IKLF
Ensembl: ENSG00000102554
RefSeq RNA: NM_001286818.2, NM_001730.5, XM_047430553.1, XM_054374881.1
RefSeq protein: NP_001273747.1, NP_001721.2, XP_047286509.1, XP_054230856.1

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II cellular response to endothelin

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm transcription regulator complex

Pathways

Developmental Biology Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Adipogenesis Adipogenesis Mesodermal commitment pathway White fat cell differentiation Transcriptional cascade regulating adipogenesis Kynurenine Pathway and links to Cellular Senescence

via MyGene.info

Gene · Ensembl

KLF transcription factor 5

Symbol: KLF5
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:73,054,976-73,077,586
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 37520
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/688
genomic end: 73077541
genomic start: 73629114
chromosome: human chromosome 13
cytogenetic location: 13q22.1

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

7 sections

Contents

Function
Interactions
Clinical significance
See also
References
Further reading
External links

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

== Function ==

Excerpted from Wikipedia’s “KLF5” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 13 Transcription factors