Klotho

Protein · UniProt

Klotho

Gene

KL

Organism

Homo sapiens (Human)

Length

1,012 aa

Molecular mass

116,181 Da

Evidence

1: Evidence at protein level

Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (By similarity). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (By similarity). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (By similarity)

• COMPLETED
  New Heart Failure Biomarkers in Early Stage Chronic Kidney Disease-Mineral and Bone DisorderPr. Semir Nouira · NCT03307707
• PHASE1RECRUITING
  Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in HumansMinicircle · NCT07216781
• PHASE4NOT_YET_RECRUITING
  IMPACT OF SUPPLEMENTATION WITH LOW MOLECULAR WEIGHT HYDROLYZED COLLAGEN AND VERISOL ON THE EXPRESSION OF LINES, SKIN QUALITY, AND LEVELS OF KLOTHO, VEGF, AND TGF-BETA IN THE EYE REGIONFederal University of São Paulo · NCT06971029
• UNKNOWN
  Serum Levels of Klotho as a Possible Biomarker of Peripheral Artery DiseaseFondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05757271
• UNKNOWN
  Factors Related to the Progression of Chronic Kidney DiseaseAnkara Education and Research Hospital · NCT01317173
• NOT_YET_RECRUITING
  Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary SyndromeMeenakshi Ammal Dental College and Hospital · NCT07504744

via ClinicalTrials.gov