Kynureninase
Kynureninase or L-Kynurenine hydrolase (KYNU) () is a pyridoxal-phosphate dependent enzyme that catalyses the cleavage of kynurenine into anthranilic acid. It can also act on 3-hydroxykynurenine (to produce 3-hydroxyanthranilate) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.
Key facts
- Enzyme.Name
- kynureninase
- Enzyme.EC_number
- 3.7.1.3
- Enzyme.CAS_number
- 9024-78-6
- Enzyme.GO_code
- 0030429
- Enzyme.image
- Kynureninase2HZP.jpg
- Enzyme.caption
- Crystal structure of Homo sapiens kynureninase.
via Wikipedia infobox
Article
5 sectionsContents
- Structure
- Function
- References
- Further reading
- External links
Kynureninase or L-Kynurenine hydrolase (KYNU) () is a pyridoxal-phosphate dependent enzyme that catalyses the cleavage of kynurenine into anthranilic acid. It can also act on 3-hydroxykynurenine (to produce 3-hydroxyanthranilate) and some other (3-arylcarbonyl)-alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.
KYNU is part of the pathway for the catabolism of tryptophan and the biosynthesis of nicotinamide adenine dinucleotide (NAD) cofactors from tryptophan (Trp).