β-lactam
Sign in to saveAlso known as beta-lactam, beta-lactams
thumb|120px|right|2-Azetidinone, the simplest β-lactam A β-lactam ('''beta-lactam') ring is a four-membered lactam. A lactam is a cyclic amide, and beta''-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics. Up to 1970, most β-lactam research was concerned with the penicillin and cephalosporin groups, but since then, a wide variety of structures have been described.
Research
165,698 papers- β-lactam antibiotics: An overview from a medicinal chemistry perspective.European journal of medicinal chemistry · 2020
- Cross-reactivity in β-Lactam Allergy.The journal of allergy and clinical immunology. In practice · 2018
- A Review of β-Lactam-Associated Neutropenia and Implications for Cross-reactivity.The Annals of pharmacotherapy · 2021
- Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomized, multicentre, open-label, superiority clinical trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025
- [Beta-lactam antibiotics].Enfermedades infecciosas y microbiologia clinica · 2009
via PubMed
~4 min read
Encyclopedic overview
6 sectionsContents
- Clinical significance
- Synthesis
- Reactions
- See also
- References
- External links
thumb|120px|right|2-Azetidinone, the simplest β-lactam A β-lactam ('''beta-lactam') ring is a four-membered lactam. A lactam is a cyclic amide, and beta''-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics. Up to 1970, most β-lactam research was concerned with the penicillin and cephalosporin groups, but since then, a wide variety of structures have been described.
==Clinical significance==
Excerpted from Wikipedia’s “β-lactam” article, available under the CC BY-SA 4.0 licence.