Imipenem, sold under the brand name Primaxin among others, is a synthetic β-lactam antibiotic belonging to the carbapenems chemical class. developed by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus playing a key role in the treatment of infections not readily treated with other antibiotics. It is usually administered through intravenous injection.
{{Drugbox | verifiedrevid = 443870020 | IUPAC_name = (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | image = Imipenem.svg | image_class = skin-invert-image | image2 = Imipenem ball-and-stick model from xtal 2020.png | image_class2 = bg-transparent
| tradename = Primaxin, others | Drugs.com = | MedlinePlus = a686013 | DailyMedID = Imipenem | pregnancy_AU = B3 | legal_AU = S4 | legal_CA = Rx-only | legal_UK = POM | legal_US = Rx-only | routes_of_administration = Intramuscular, intravenous | ATC_prefix = J01 | ATC_suffix = DH51
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).