Structure via PubChem · Public domain (PubChem)
picamilon
Sign in to savePicamilon (also known as '''N-nicotinoyl-GABA, pycamilon, and pikamilon''') is a drug formed by a synthetic combination of niacin and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 and further studied in both Russia and Japan as a prodrug of GABA.
Chemical data
- Formula
- C10H12N2O3
- Molecular weight
- 208.21 g/mol
- IUPAC name
- 4-(pyridine-3-carbonylamino)butanoic acid
- SMILES
- C1=CC(=CN=C1)C(=O)NCCCC(=O)O
- InChIKey
- NAJVRARAUNYNDX-UHFFFAOYSA-N
- XLogP
- -0.4
- Polar surface area
- 79.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
56 papers- Picamilon, a γ-aminobutyric acid (GABA) analogue and marketed nootropic, is inactive against 50 biological targets.Basic & clinical pharmacology & toxicology · 2023
- [Clinical efficacy and safety of Picamilon in patients with progressive chronic cerebral ischemia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2024
- [Integrative assessment of the effectiveness and safety of outpatient use of Picamilon].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2024
- Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2010
- [Treatment of patients with chronic cerebral ischemia: experience of using the combined neuroprotective drug Picamilon Ginkgo].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 208.085
Show 5 more facts
- canonical SMILES
- C1=CC(=CN=C1)C(=O)NCCCC(=O)O
- chemical formula
- C₁₀H₁₂N₂O₃
- subject has role
- nootropic
- Commons category
- Picamilon
- native label
- Picamilonum
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Regulation
- Pharmacology
- Pharmacokinetics
- See also
- References
- External links
Picamilon (also known as '''N-nicotinoyl-GABA, pycamilon, and pikamilon') is a drug formed by a synthetic combination of niacin and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 and further studied in both Russia and Japan as a prodrug of GABA.
In Russia, picamilon is sold as a prescription drug. The rights to the drug belong to the Russian pharmaceutical company NPK ECHO ("НПК ЭХО"). It is not approved for sale in the United States and has been deemed an adulterating agent in dietary supplements, with five American companies required to remove their picamilon products from the market in November 2015. However, as recently as 2020, picamilon has been found in pharmaceutical dosages in over-the-counter supplements in the US.
Excerpted from Wikipedia’s “picamilon” article, available under the CC BY-SA 4.0 licence.