Лактоферрин
Sign in to saveAlso known as neutrophil lactoferrin, LTF, lactoferroxin, epididymis luminal protein 110, talalactoferrin, growth-inhibiting protein 12, kaliocin-1, lactoferrin
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum ("first milk") has the highest concentration, followed by human milk, then cow milk (150 mg/L).
Protein · UniProt
Lactotransferrin
- Gene
- LTF
- Organism
- Homo sapiens (Human)
- Length
- 710 aa
- Molecular mass
- 78,182 Da
- Evidence
- 1: Evidence at protein level
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
121 registered- PHASE3COMPLETEDLactoferrin Infant Feeding Trial - LIFT_CanadaDr. Elizabeth Asztalos · NCT03367013
- PHASE4COMPLETEDLactoferrin Versus Iron Supplement in Irondeficiency Anemia and Weight Loss in Obese ChildrenAin Shams University · NCT04014855
- PHASE4UNKNOWNthe Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic TonsillitisSouth Valley University · NCT03748043
- PHASE4UNKNOWNComparative Study Between Oral Liposomal Iron,Iron Supported Lactoferrin and IV Iron Dextran in CKD ChildrenMenoufia University · NCT05714176
- PHASE1/PHASE2WITHDRAWNA Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Proven CandidaemiaAM-Pharma · NCT00509834
- NACOMPLETEDEffect of Infant Formula With Bovine Lactoferrin and Low Iron Concentration on Infant Health and Immune FunctionUmeå University · NCT02103205
Wikidata facts
- Instance of
- protein
- Image
- Lactoferrin.png
Show 4 more facts
- Commons category
- Lactoferrin
- found in taxon
- Homo sapiens
- cell component
- extracellular exosome
- exact match
- purl.uniprot.org/uniprot/P02788
via Wikidata · CC0
Article · Русский
Лактоферрин — полифункциональный белок из семейства трансферринов. Лактоферрин является глобулярным гликопротеином с молекулярной массой около 80 кДа и широко представлен в различных секреторных жидкостях, таких как молоко, слюна, слёзы, секреты носовых желез. Лактоферрин является одним из компонентов иммунной системы организма, принимает участие в системе неспецифического гуморального иммунитета, регулирует функции иммунокомпетентных клеток и является белком острой фазы воспаления. Белок взаимодействует с ДНК и РНК, полисахаридами, гепарином, причем некоторые из своих биологических функций лактоферрин проявляет в виде комплексов с этими лигандами.
Abstract from DBpedia / Wikipedia · CC BY-SA