liver failure
Sign in to saveAlso known as reduced liver function, hepatic insufficiency, liver insufficiency
inability of the liver to perform its normal functions
OverviewAI-generated
Liver failure is a medical condition classified under the ICD-10 code for hepatic failure, unspecified without coma. It is a subject of extensive academic and clinical research, with 96,402 related entries indexed in PubMed and 1,131 associated studies listed on ClinicalTrials.gov.
The condition is documented in various medical databases and encyclopedic resources. It has been referenced by 810 other encyclopedia articles, indicating its presence across multiple informational contexts.
Synthesized by Vinony from 8 facts across 5 sources: Wikidata, PubMed, ClinicalTrials.gov, Medline, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Other names
- Hepatic insufficiency, liver dysfunction
- Specialty
- Gastroenterology , hepatology
- Symptoms
- abdominal inflammation, fluid retention , hyperglycemia , nausea , vomiting , jaundice , acute or chronic fatigue , hyponatremia , hypokalemia , respiratory alkalosis , metabolic acidosis , bilirubinuria , glycosuria , pruritus
- Risk factors
- Excessive consumption of alcohol , fatty foods; obesity; Type 2 Diabetes ; anabolic steroids ; sharing or reusing syringes
via Wikipedia infobox
Health references
- ICD-10
- K72.90 — Hepatic failure, unspecified without coma
Research
96,402 papers- Neonatal acute liver failure.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2016
- Pathophysiology of Acute Liver Failure.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020
- Acute liver failure.The New England journal of medicine · 2013
- Acute Liver Failure in Children.Critical care nursing clinics of North America · 2022
- Pediatric Acute Liver Failure.Critical care clinics · 2022
via PubMed
Clinical Trials
1,131 registered- NATERMINATEDRe-treatment of HCV Following DAA FailureSanjay Gandhi Postgraduate Institute of Medical Sciences · NCT03483987
- PHASE3COMPLETEDA 6-month Efficacy, Safety, and Tolerability Study of Rifaximin In Preventing Hepatic EncephalopathyBausch Health Americas, Inc. · NCT00298038
- PHASE2COMPLETEDEvaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron OverloadNovartis Pharmaceuticals · NCT00600938
- PHASE4RECRUITINGEffects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic HyponatremiaUniversity Hospital, Basel, Switzerland · NCT04447911
- PHASE1/PHASE2NOT_YET_RECRUITINGEDN Combined With TACE/HAIC and Second-Line Immune-Targeted Treatment Versus TACE/HAIC Alone in Locally Advanced HCC With Portal Vein Tumor Thrombosis After First-Line Therapy Failure: A Prospective, Multicenter, Randomized Controlled TrialZhongda Hospital · NCT07187284
- COMPLETEDLong-Term Study on Safety and Immunogenicity of HEPLISAV™ and Engerix-B® in Adults With Chronic Kidney DiseaseDynavax Technologies Corporation · NCT01282762
Wikidata facts
- Instance of
- clinical sign
- Image
- Depiction of a liver failure patient.png
Show 3 more facts
- health specialty
- hepatology
- exact match
- purl.obolibrary.org/obo/HP_0001399
- Commons category
- Liver failure
via Wikidata · CC0
~3 min read
Encyclopedic overview
Liver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis). Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized.
Acute
Excerpted from Wikipedia’s “liver failure” article, available under the CC BY-SA 4.0 licence.