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colestyramine
Sign in to saveAlso known as cholestyramine resin
Colestyramine (INN) or cholestyramine (USAN) (trade names Questran, Questran Light, Cholybar, Olestyr, Quantalan, Vasosan) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer.
Chemical data
- Formula
- C21H30ClN
- Molecular weight
- 331.9 g/mol
- IUPAC name
- [4-[3-(4-ethylphenyl)butyl]phenyl]-trimethylazanium chloride
- SMILES
- CCC1=CC=C(C=C1)C(C)CCC2=CC=C(C=C2)[N+](C)(C)C.[Cl-]
- InChIKey
- KNDHRUPPBXRELB-UHFFFAOYSA-M
- Polar surface area
- 0 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Research
3,804 papers- Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.Clinical pharmacokinetics · 2005
- Systematic review with meta-analysis: the prevalence of bile acid malabsorption and response to colestyramine in patients with chronic watery diarrhoea and previous cholecystectomy.Alimentary pharmacology & therapeutics · 2019
- Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease.Hepatology communications · 2023
- Cholestyramine.Canadian Medical Association journal · 1971
- Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects.Neurogastroenterology and motility · 2012
via PubMed
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Encyclopedic overview
7 sectionsContents
- Medical uses
- Research
- Available forms
- Dosage
- Side effects
- Drug interactions
- Notes and references
Colestyramine (INN) or cholestyramine (USAN) (trade names Questran, Questran Light, Cholybar, Olestyr, Quantalan, Vasosan) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer.
Colestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, which are then excreted in the feces. As a result of this loss of bile acids, more plasma cholesterol is converted to bile acids in the liver to normalise levels. This conversion of cholesterol into bile acids lowers plasma cholesterol levels.
Excerpted from Wikipedia’s “colestyramine” article, available under the CC BY-SA 4.0 licence.