Structure via PubChem · Public domain (PubChem)
lormetazepam
Sign in to saveAlso known as chlorotemazepam, methyllorazepam, WY-4082
Lormetazepam, sold under the brand name Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy benzodiazepine derivative and temazepam analogue. It possesses hypnotic, anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 461743593
- Drug.image
- Lormetazepam.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.image2
- Lormetazepam3d.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 170px
- Drug.tradename
- Noctamid, Loramet, others
- Drug.pregnancy_category
- D
- Drug.legal_BR
- B1
- Drug.legal_CA
- Schedule IV
- Drug.legal_DE
- Rx-only/Anlage III
- Drug.legal_US
- Schedule IV
- Drug.routes_of_administration
- Oral, intravenous
- Drug.class
- Benzodiazepine
- Drug.ATC_prefix
- N05
via Wikipedia infobox
Chemical data
- Formula
- C16H12Cl2N2O2
- Molecular weight
- 335.2 g/mol
- IUPAC name
- 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl
- InChIKey
- FJIKWRGCXUCUIG-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 52.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- anxiety, Dementia, depressive disorder, Sleep Disorder
via ChEMBL · EBI
Research
303 papers- Lormetazepam.2006
- The role of benzodiazepines in common conditions: a narrative review focusing on lormetazepam.International clinical psychopharmacology · 2024
- [Lormetazepam].Revista de medicina de la Universidad de Navarra · 1984
- Dependence liability of lormetazepam: are all benzodiazepines equal? The case of the new i.v. lormetazepam for anesthetic procedures.Journal of neural transmission (Vienna, Austria : 1996) · 2020
- Lormetazepam in oral solution: a formulation at risk of high-dose use.Internal and emergency medicine · 2019
via PubMed
Wikidata facts
- Subclass of
- benzodiazepine drug
- Mass
- 334.027583
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₆H₁₂Cl₂N₂O₂
- canonical SMILES
- CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl
- Commons category
- Lormetazepam
- found in taxon
- Triticum aestivum
- defined daily dose
- 1
- significant drug interaction
- sodium oxybate
Sources (3)
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Tolerance, dependence, and withdrawal
- Pharmacology
- Chemistry
- Stereochemistry
- Industry
- Brand names
- References
- External links
Lormetazepam, sold under the brand name Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy benzodiazepine derivative and temazepam analogue. It possesses hypnotic, anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties.
It was patented in 1961 and came into medical use in 1980. Lormetazepam is not approved for sale in the United States or Canada. It is licensed in the UK as 0.5 and 1mg tablets for short-term treatment (2–4 weeks) of moderately severe insomnia. It is licensed in the Netherlands as 1 and 2mg tablets, under the brand names Loramet and Noctamid and as generic, available from several manufacturers. It is sold in Poland as Noctofer. It is also sold in France as generic as 1 and 2mg tablets, with a maximum prescription duration of 4 weeks. A Dutch analysis stated that lormetazepam could be suitable to be included in drug prescribing formularies, although zolpidem, zopiclone, and temazepam appear better.
Excerpted from Wikipedia’s “lormetazepam” article, available under the CC BY-SA 4.0 licence.