LRP6
Sign in to saveAlso known as ADCAD2, STHAG7, LDL receptor related protein 6
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
Gene data
LRP6- Name
- LDL receptor related protein 6
- Type
- protein-coding
- Position
- 12,116,025–12,267,193 (−)
- Aliases
- ADCAD2, EVR8, OPTA4, STHAG7
- Ensembl
- ENSG00000070018
- RefSeq RNA
- NM_001414244.1, NM_001414245.1, NM_001414246.1, NM_001414247.1, NM_001414248.1
- RefSeq protein
- NP_001401173.1, NP_001401174.1, NP_001401175.1, NP_001401176.1, NP_001401177.1
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
LDL receptor related protein 6
- Symbol
- LRP6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:12,116,025-12,267,193
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 1747
- genetic association
- coronary artery disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4040
- chromosome
- human chromosome 12
- genomic start
- 12268959
- genomic end
- 12267044
- cytogenetic location
- 12p13.2
- expressed in
- sural nerve
Sources (8)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Function
- Interactions
- Clinical significance
- References
- Further reading
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
==Structure== LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four YWTD β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats, followed by three LDLR type A repeats. Most extracellular ligands bind to LRP5 and LRP6 at the β-propellers. Each protein has a single-pass, 22-amino-acid transmembrane helix followed by a 207-amino-acid segment that is internal to the cell.
Excerpted from Wikipedia’s “LRP6” article, available under the CC BY-SA 4.0 licence.