LTA

Name

lymphotoxin alpha

Type

protein-coding

Chromosome

HSCHR6_MHC_QBL_CTG1

Position

2,827,871–2,830,143 (+)

Aliases

LT, TNFB, TNFSF1, TNLG1E

Ensembl

ENSG00000173503

RefSeq RNA

NM_000595.4, NM_001159740.2, XM_047418773.1, XM_054329823.1, XM_054329824.1

RefSeq protein

NP_000586.2, NP_001153212.1, XP_047274729.1, XP_054185798.1, XP_054185799.1

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].

via MyGene.info

Gene · Ensembl

lymphotoxin alpha

Symbol

LTA

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR6_MHC_MANN_CTG1:2,877,095-2,879,365

Strand

Forward (+)

Assembly

GRCh38