Also known as TNFC, TNFSF3, p33, Lymphotoxin beta, TNLG1C
protein-coding gene in the species Homo sapiens
Gene data
LTB- Name
- lymphotoxin beta
- Type
- protein-coding
- Position
- 31,580,525–31,582,522 (−)
- Aliases
- TNFC, TNFSF3, TNLG1C, p33
- Ensembl
- ENSG00000236925
- RefSeq RNA
- NM_002341.2, NM_009588.1
- RefSeq protein
- NP_002332.1, NP_033666.1
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lymphotoxin beta
- Symbol
- LTB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MANN_CTG1:2,885,596-2,887,563
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI