lumefantrine

Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. This combination is frequently the first-line medication for Plasmodium falciparum malaria. Lumefantrine has a much longer half-life compared to artemether (3-6 days vs. 2 hours), and is therefore thought to clear any residual parasites that remain after combination treatment.

== Mechanism of action == The exact mechanism by which lumefantrine acts on erythrocytic stages of Plasmodium falciparum is unknown. However, it was shown to exert its action through possible two mechanisms: inhibiting β-hematin formation by creating complexes with hemin inhibiting nucleic acid and protein synthesis