Structure via PubChem · Public domain (PubChem)
lumefantrine
Sign in to saveAlso known as 2-dibutylamino-1-[2,7-dichloro-9-(4-chloro-benzylidene)-9H-fluoren-4-yl]-ethanol, benflumetol, DL-benflumelol, 2-dibutylamino-1-{2,7-dichloro-9-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-9H-fluoren-4-yl}-ethanol, dl-benflumelol, (±)-2,7-dichloro-9-[(Z)-p-chlorobenzylidene]-α-[(dibutylamino)methyl]fluorene-4-methanol, (+-)-2,7-dichloro-9-[(Z)-p-chlorobenzylidene]-alpha-[(dibutylamino)methyl]fluorene-4-methanol
Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. This combination is frequently the first-line medication for Plasmodium falciparum malaria. Lumefantrine has a much longer half-life compared to artemether (3-6 days vs. 2 hours), and is therefore thought to clear any residual parasites that remain after combination treatment.
Chemical data
- Formula
- C30H32Cl3NO
- Molecular weight
- 528.9 g/mol
- IUPAC name
- 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
- SMILES
- CCCCN(CCCC)CC(C1=CC(=CC\2=C1C3=C(/C2=C/C4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O
- InChIKey
- DYLGFOYVTXJFJP-MYYYXRDXSA-N
- XLogP
- 8.7
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
2,191 papers- Artemether-lumefantrine: an option for malaria.The Annals of pharmacotherapy · 2012
- Artemether-lumefantrine for uncomplicated malaria: a systematic review.Tropical medicine & international health : TM & IH · 2004
- Artemether-lumefantrine (four-dose regimen) for treating uncomplicated falciparum malaria.The Cochrane database of systematic reviews · 2006
- Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria.The Cochrane database of systematic reviews · 2005
- Artemether-lumefantrine for treating uncomplicated falciparum malaria.The Cochrane database of systematic reviews · 2002
via PubMed
~4 min read
Encyclopedic overview
7 sectionsContents
- Mechanism of action
- Metabolism
- Adverse effects
- History
- Research
- See also
- References
Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. This combination is frequently the first-line medication for Plasmodium falciparum malaria. Lumefantrine has a much longer half-life compared to artemether (3-6 days vs. 2 hours), and is therefore thought to clear any residual parasites that remain after combination treatment.
== Mechanism of action == The exact mechanism by which lumefantrine acts on erythrocytic stages of Plasmodium falciparum is unknown. However, it was shown to exert its action through possible two mechanisms: inhibiting β-hematin formation by creating complexes with hemin inhibiting nucleic acid and protein synthesis
Excerpted from Wikipedia’s “lumefantrine” article, available under the CC BY-SA 4.0 licence.