Structure via PubChem · Public domain (PubChem)
(RS)-mianserin
Sign in to saveAlso known as (+-)-athymil, ORG GB 94, 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,F)pyrazino(1,2-a)azepine
Mianserin, sold as Tolvon and other brand names, is an atypical antidepressant used primarily for treating depression in Europe and other countries. It is a tetracyclic antidepressant (TeCA) and is closely related to mirtazapine in terms of chemical structure, actions, and effects, although mianserin has greater noradrenergic activity and less 5-HT3 receptor antagonism.
Chemical data
- Formula
- C18H20N2
- Molecular weight
- 264.4 g/mol
- IUPAC name
- 5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
- SMILES
- CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42
- InChIKey
- UEQUQVLFIPOEMF-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- anxiety, Dementia, depressive disorder, schizophrenia
via ChEMBL · EBI
Research
1 papers- Isoform-selective metabolism of mianserin by cytochrome P-450 2D.Drug metabolism and disposition: the biological fate of chemicals · 1999
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 264.163
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₈H₂₀N₂
- canonical SMILES
- CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42
- World Health Organisation international non-proprietary name
- mianserin
- Commons category
- Mianserin
- defined daily dose
- 60
- significant drug interaction
- droperidol
via Wikidata · CC0
~7 min read
Encyclopedic overview
18 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Withdrawal
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- Research
- References
- Further reading
Mianserin, sold as Tolvon and other brand names, is an atypical antidepressant used primarily for treating depression in Europe and other countries. It is a tetracyclic antidepressant (TeCA) and is closely related to mirtazapine in terms of chemical structure, actions, and effects, although mianserin has greater noradrenergic activity and less 5-HT3 receptor antagonism.
==Medical uses== Mianserin is used at higher doses (30–90 mg/day) for the treatment of major depressive disorder. At lower doses (around 10 mg/day), it is used to treat insomnia.
Excerpted from Wikipedia’s “(RS)-mianserin” article, available under the CC BY-SA 4.0 licence.