MAP1LC3A

Also known as ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, microtubule associated protein 1 light chain 3 alpha

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene. Two transcript variants encoding different isoforms have been found for this gene.

Gene data

MAP1LC3A

Name: microtubule associated protein 1 light chain 3 alpha
Type: protein-coding
Position: 34,546,838–34,560,357 (+)
Aliases: ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3
Ensembl: ENSG00000101460
RefSeq RNA: NM_032514.4, NM_181509.3, XM_011529084.3, XM_011529085.3, XM_047440558.1
RefSeq protein: NP_115903.1, NP_852610.1, XP_011527386.1, XP_011527387.1, XP_047296514.1

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012].

Pathways

Ferroptosis - Homo sapiens (human)Macroautophagy Mitophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Autophagy Selective autophagy Nanoparticle triggered autophagic cell death Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling Ferroptosis

via MyGene.info

Gene · Ensembl

microtubule associated protein 1 light chain 3 alpha

Symbol: MAP1LC3A
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:34,546,838-34,560,357
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 12021
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84557
genomic end: 33148149
genomic start: 33134658
chromosome: human chromosome 20
cytogenetic location: 20q11.22
expressed in: anterior pituitary

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

Function
Regulation
References
Further reading

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene. Two transcript variants encoding different isoforms have been found for this gene.

== Function ==

Excerpted from Wikipedia’s “MAP1LC3A” article, available under the CC BY-SA 4.0 licence.