MAP2K2
Sign in to saveAlso known as CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
gen de la especie Homo sapiens
Gene data
MAP2K2- Name
- mitogen-activated protein kinase kinase 2
- Type
- protein-coding
- Position
- 4,090,316–4,124,238 (−)
- Aliases
- CFC4, MAPKK2, MEK2, MKK2, PRKMK2
- Ensembl
- ENSG00000126934
- RefSeq RNA
- NM_001440688.1, NM_001440689.1, NM_030662.4
- RefSeq protein
- NP_001427617.1, NP_001427618.1, NP_109587.1
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase 2
- Symbol
- MAP2K2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:4,090,316-4,124,238
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MAP2K2 PDB 1s9i.png
Show 8 more facts
- HomoloGene ID
- 48591
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5605
- genomic end
- 4124122
- genomic start
- 4090319
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.3
- expressed in
- prefrontal cortex
Sources (4)
via Wikidata · CC0
Article · Español
La MAP quinasa quinasa específica dual 2 (MAP2K2) es una enzima codificada en humanos por el gen MAP2K2. Esta quinasa es una proteína quinasa específica dual, que pertenece a la familia de las MAP quinasa quinasas. MAP2K2 es conocida por desempeñar un papel crucial en la transducción de señales de factores de crecimiento mitógenos. Es capaz de fosforilar y activar a los complejos MAPK1/ERK2 y /. La activación de esta quinasa es dependiente de fosforilación de Ser/Thr por MAP quinasa quinasa quinasas. La inhibición o degradación de esta quinasa parece estar implicada en la patogénesis de Yersinia y del carbunco.
Abstract from DBpedia / Wikipedia · CC BY-SA