MAP3K14
Sign in to saveAlso known as FTDCR1B, HS, HSNIK, NIK, mitogen-activated protein kinase kinase kinase 14
gene umano
Gene data
MAP3K14- Name
- mitogen-activated protein kinase kinase kinase 14
- Type
- protein-coding
- Position
- 45,263,119–45,317,112 (−)
- Aliases
- FTDCR1B, HS, HSNIK, IMD112, NIK
- Ensembl
- ENSG00000006062
- RefSeq RNA
- NM_003954.5, XM_011525441.3, XM_047436997.1, XM_047436998.1, XM_054317683.1
- RefSeq protein
- NP_003945.2, XP_011523743.1, XP_047292953.1, XP_047292954.1, XP_054173658.1
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
MAPK signaling pathway - Homo sapiens (human)NF-kappa B signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)C-type lectin receptor signaling pathway - Homo sapiens (human)T cell receptor signaling pathway - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Intestinal immune network for IgA production - Homo sapiens (human)Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase 14
- Symbol
- MAP3K14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:45,263,119-45,317,112
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2940
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9020
- chromosome
- human chromosome 17
- cytogenetic location
- 17q21.31
- genomic start
- 45263119
- genomic end
- 45317029
- expressed in
- anterior pituitary
Sources (3)
via Wikidata · CC0