Structure via PubChem · Public domain (PubChem)
maribavir
Sign in to saveMaribavir, sold under the brand name Livtencity, is an antiviral medication that is used to treat post-transplant cytomegalovirus (CMV). Maribavir is a cytomegalovirus pUL97 kinase inhibitor that works by preventing the activity of human cytomegalovirus enzyme pUL97, thus blocking virus replication.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 450846483
- Drug.image
- Maribavir.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Livtencity
- Drug.DailyMedID
- Maribavir
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J05
- Drug.ATC_suffix
- AX10
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 176161-24-3
- Drug.PubChem
- 471161
- Drug.DrugBank
- DB06234
via Wikipedia infobox
Chemical data
- Formula
- C15H19Cl2N3O4
- Molecular weight
- 376.2 g/mol
- IUPAC name
- (2S,3S,4R,5S)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
- SMILES
- CC(C)NC1=NC2=CC(=C(C=C2N1[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O)Cl)Cl
- InChIKey
- KJFBVJALEQWJBS-XUXIUFHCSA-N
- XLogP
- 2.2
- Polar surface area
- 99.8 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- viral disease, cytomegalovirus infection
via ChEMBL · EBI
Research
359 papers- Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results From a Phase 3 Randomized Clinical Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
- Maribavir.2012
- Maribavir.Hospital pharmacy · 2023
- Maribavir: Mechanism of action, clinical, and translational science.Clinical and translational science · 2024
- Maribavir: First Approval.Drugs · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 375.075
Show 4 more facts
- chemical formula
- C₁₅H₁₉Cl₂N₃O₄
- isomeric SMILES
- CC(C)NC1=NC2=CC(=C(C=C2N1[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O)Cl)Cl
- canonical SMILES
- CC(C)NC1=NC2=CC(=C(C=C2N1C3C(C(C(O3)CO)O)O)Cl)Cl
- Commons category
- Maribavir
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Adverse effects
- Contraindications
- History
- Society and culture
- Legal status
- References
- External links
Maribavir, sold under the brand name Livtencity, is an antiviral medication that is used to treat post-transplant cytomegalovirus (CMV). Maribavir is a cytomegalovirus pUL97 kinase inhibitor that works by preventing the activity of human cytomegalovirus enzyme pUL97, thus blocking virus replication.
The most common side effects include taste disturbance, nausea, diarrhea, vomiting and fatigue.
Excerpted from Wikipedia’s “maribavir” article, available under the CC BY-SA 4.0 licence.