MCM2

Also known as BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

Gene data

MCM2

Name: minichromosome maintenance complex component 2
Type: protein-coding
Position: 127,598,223–127,622,437 (+)
Aliases: BM28, CCNL1, CDCL1, D3S3194, DFNA70, MITOTIN, cdc19
Ensembl: ENSG00000073111
RefSeq RNA: NM_004526.4, NR_073375.2, XM_024453531.2, XM_054346560.1
RefSeq protein: NP_004517.2, XP_024309299.1, XP_054202535.1

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012].