MCM3
Sign in to saveAlso known as HCC5, P1-MCM3, P1.h, RLFB, minichromosome maintenance complex component 3
DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.
Gene data
MCM3- Name
- minichromosome maintenance complex component 3
- Type
- protein-coding
- Aliases
- HCC5, P1-MCM3, P1.h, RLFB
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1791
- exact match
- identifiers.org/ncbigene/4172
- genomic end
- 52149679
- genomic start
- 52128807
- cytogenetic location
- 6p12.2
Sources (4)
via Wikidata · CC0
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Article
5 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.
== Function ==