MCM3

Name

minichromosome maintenance complex component 3

Type

protein-coding

Position

52,264,009–52,284,881 (−)

Aliases

HCC5, P1-MCM3, P1.h, RLFB

Ensembl

ENSG00000112118

RefSeq RNA

NM_001270472.3, NM_001366369.2, NM_001366370.2, NM_001366371.2, NM_001366372.2

RefSeq protein

NP_001257401.2, NP_001353298.1, NP_001353299.1, NP_001353300.1, NP_001353301.1

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018].

via MyGene.info

Gene · Ensembl

minichromosome maintenance complex component 3

Symbol

MCM3

Biotype

Protein coding

Organism

Homo sapiens

Location

6:52,264,009-52,284,881

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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