MCM7

Also known as CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104, minichromosome maintenance complex component 7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

In the Vinony graph

Within Vinony's link graph, MCM7 is referenced by 104 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 7.

Its subject is documented across 6 Wikipedia language editions.

Gene data

MCM7

Name: minichromosome maintenance complex component 7
Type: protein-coding
Position: 100,092,233–100,101,940 (−)
Aliases: CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Ensembl: ENSG00000166508
RefSeq RNA: NM_001278595.2, NM_001439271.1, NM_001439272.1, NM_001439273.1, NM_005916.5
RefSeq protein: NP_001265524.1, NP_001426200.1, NP_001426201.1, NP_001426202.1, NP_005907.3

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].