Also known as ARAP, MK, NEGF2, midkine (neurite growth-promoting factor 2), midkine
gen de la especie Homo sapiens
Gene data
MDK- Name
- midkine
- Type
- protein-coding
- Position
- 46,380,748–46,383,837 (+)
- Aliases
- ARAP, MK, NEGF2
- Ensembl
- ENSG00000110492
- RefSeq RNA
- NM_001012333.3, NM_001012334.2, NM_001270550.1, NM_001270551.3, NM_001270552.3
- RefSeq protein
- NP_001012333.1, NP_001012334.1, NP_001257479.1, NP_001257480.1, NP_001257481.1
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
midkine
- Symbol
- MDK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:46,380,748-46,383,837
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MDK PDB 1mkc.png
Show 7 more facts
- HomoloGene ID
- 1792
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4192
- chromosome
- human chromosome 11
- genomic start
- 46402306
- genomic end
- 46405375
- cytogenetic location
- 11p11.2
via Wikidata · CC0
Article · Español
Midkina es una sustancia en estudio para el tratamiento de muchos tipos de cánceres. MK-0646 se adhiere a una proteína llamada receptor del factor de crecimiento tipo insulina (IGF1R) en la superficie de las células. Esto puede prevenir que las células crezcan cuando el IGF está presente. También puede eliminar las células cancerosas. MK-0646 es un tipo de anticuerpo monoclonal. También se llama anti-IGF1R anticuerpo monoclonal recombinado MK-0646.
Abstract from DBpedia / Wikipedia · CC BY-SA