Structure via PubChem · Public domain (PubChem)
mecloqualone
Sign in to saveMecloqualone (Nubarene, Casfen) is a quinazolinone-class GABAergic and is an analogue of methaqualone that was first made in 1960 and marketed mainly in France and some other European countries. It has sedative, hypnotic, and anxiolytic properties caused by its agonist activity at the β subtype of the GABAa receptor, and was used for the treatment of insomnia. Mecloqualone is faster-acting but shorter-lasting than methaqualone and so was used only as a sleeping pill, in contrast to methaqualone, which was used as a general-purpose anxiolytic as well. Mecloqualone was never as widely used as me
Chemical data
- Formula
- C15H11ClN2O
- Molecular weight
- 270.71 g/mol
- IUPAC name
- 3-(2-chlorophenyl)-2-methylquinazolin-4-one
- SMILES
- CC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3Cl
- InChIKey
- SFITWQDBYUMAPS-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 270.056
Show 3 more facts
- chemical formula
- C₁₅H₁₁ClN₂O
- canonical SMILES
- CC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3Cl
- Commons category
- Mecloqualone
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Mecloqualone (Nubarene, Casfen) is a quinazolinone-class GABAergic and is an analogue of methaqualone that was first made in 1960 and marketed mainly in France and some other European countries. It has sedative, hypnotic, and anxiolytic properties caused by its agonist activity at the β subtype of the GABAa receptor, and was used for the treatment of insomnia. Mecloqualone is faster-acting but shorter-lasting than methaqualone and so was used only as a sleeping pill, in contrast to methaqualone, which was used as a general-purpose anxiolytic as well. Mecloqualone was never as widely used as methaqualone and is no longer prescribed because of concerns about its potential for abuse and overdose. In the United States it is a Schedule I non-narcotic (depressant) controlled substance with an ACSCN of 2572 and 30 grams annual aggregate manufacturing quota.
== See also == Afloqualone Etaqualone Methylmethaqualone Mebroqualone Cloroqualone Diproqualone Gamma-Aminobutyric acid
Excerpted from Wikipedia’s “mecloqualone” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0