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GeneQ18041261· pop 6· linked from 2 articles

MED18

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Also known as p28b, mediator complex subunit 18, SRB5

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

Gene data

MED18

Name: mediator complex subunit 18
Type: protein-coding
Position: 28,329,002–28,335,965 (+)
Aliases: SRB5, p28b
Ensembl: ENSG00000130772
RefSeq RNA: NM_001127350.2, NM_017638.3, XM_005245914.5, XM_054332155.1, XM_054337204.1
RefSeq protein: NP_001120822.1, NP_060108.2, XP_005245971.1, XP_054188130.1, XP_054193179.1

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II RNA polymerase II preinitiation complex assembly positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II

Molecular function

transcription coregulator activity transcription coregulator activity protein binding

Cellular component

nucleus nucleus nucleoplasm mediator complex mediator complex mediator complex core mediator complex

Pathways

Developmental Biology Developmental Biology Metabolism Disease PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Metabolism of lipids Infectious disease

via MyGene.info

Gene · Ensembl

mediator complex subunit 18

Symbol: MED18
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:28,329,002-28,335,976
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: The IDRc bound human core Mediator complex - Mediator of RNA polymerase II transcription subunit 18 (2) 8TRH.png

Show 5 more facts

HomoloGene ID: 9756
exact match: identifiers.org/ncbigene/54797
genomic end: 28335965
genomic start: 28655513
cytogenetic location: 1p35.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

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Contents

Function
See also
References

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

== Function ==

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Categories

Genes on human chromosome 1