MEF2D

Also known as myocyte enhancer factor 2D

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.

Gene data

MEF2D

Name: myocyte enhancer factor 2D
Type: protein-coding
Position: 156,463,727–156,501,266 (−)
Ensembl: ENSG00000291761
RefSeq RNA: NM_001271629.2, NM_005920.4, XM_005245169.5, XM_005245170.4, XM_006711330.4
RefSeq protein: NP_001258558.1, NP_005911.1, XP_005245226.1, XP_005245227.1, XP_006711393.1

This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].

Gene Ontology

Biological process

adult heart development muscle organ development cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II animal organ development positive regulation of vascular associated smooth muscle cell proliferation

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm

Pathways

cGMP-PKG signaling pathway - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Developmental Biology Mitochondrial biogenesis Signal Transduction Signal Transduction Signaling by NTRKs Signaling by NTRKs Organelle biogenesis and maintenance

via MyGene.info

Gene · Ensembl

myocyte enhancer factor 2D

Symbol: MEF2D
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:156,463,727-156,501,266
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Research

568 papers

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.Nature communications · 2016
Mef2d potentiates type-2 immune responses and allergic lung inflammation.Science (New York, N.Y.) · 2024
The Molecular and Biological Function of MEF2D in Leukemia.Advances in experimental medicine and biology · 2024
MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis.Nature cancer · 2025
MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation.Cancer letters · 2024

via PubMed

Wikidata facts

Image: Protein MEF2D PDB 1c7u.png

Show 5 more facts

HomoloGene ID: 4327
exact match: identifiers.org/ncbigene/4209
genomic end: 156500779
genomic start: 156433519
cytogenetic location: 1q22

Sources (6)

via Wikidata · CC0

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Article

5 sections

Contents

Interactions
See also
References
Further reading
External links

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.

== Interactions == MEF2D has been shown to interact with: CABIN1, EP300, MAPK7, Myocyte-specific enhancer factor 2A, NFATC2 Sp1 transcription factor, and YWHAQ.