ملفالان

Also known as MLP673, Alkeran®, CB-3025, L-phenylalanine mustard (L-PAM), L-sarcolysine, melfalan, Sarcolysin®, Phenylalanine nitrogen mustard

Melphalan, sold under the brand name Alkeran among others, is a chemotherapy medication used to treat multiple myeloma; malignant lymphoma; lymphoblastic and myeloblastic leukemia; childhood neuroblastoma; ovarian cancer; mammary adenocarcinoma; and uveal melanoma. It is taken by mouth or by injection into a vein.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 462248349
Drug.image: Melphalan.svg
Drug.image_class: skin-invert-image
Drug.width: 240
Drug.image2: Melphalan ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.tradename: Alkeran, Evomela, Hepzato, Ivra, Phelinun, others
Drug.MedlinePlus: a682220
Drug.DailyMedID: Melphalan
Drug.routes_of_administration: By mouth, intravenous, intra-arterial
Drug.ATC_prefix: L01
Drug.ATC_suffix: AA03
Drug.legal_AU: S4
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.bioavailability: 25–89% (By mouth)
Drug.metabolism: Hydrolysis to inactive metabolites

via Wikipedia infobox

Chemical data

Formula: C13H18Cl2N2O2
Molecular weight: 305.2 g/mol
IUPAC name: (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl
InChIKey: SGDBTWWWUNNDEQ-LBPRGKRZSA-N
XLogP: -0.5
Polar surface area: 66.6 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0