Melfalan

Key facts

Drug.Watchedfields

changed

Drug.verifiedrevid

462248349

Drug.image

Melphalan.svg

Drug.image_class

skin-invert-image

Drug.width

240

Drug.image2

Melphalan ball-and-stick.png

Drug.image_class2

bg-transparent

Drug.tradename

Alkeran, Evomela, Hepzato, Ivra, Phelinun, others

Drug.MedlinePlus

a682220

Drug.DailyMedID

Melphalan

Drug.routes_of_administration

By mouth, intravenous, intra-arterial

Drug.ATC_prefix

L01

Drug.ATC_suffix

AA03

Drug.legal_AU

S4

Drug.legal_US

Rx-only

Drug.legal_EU

Rx-only

Drug.bioavailability

25–89% (By mouth)

Drug.metabolism

Hydrolysis to inactive metabolites

via Wikipedia infobox

Chemical data

Formula

C13H18Cl2N2O2

Molecular weight

305.2 g/mol

IUPAC name

(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

SMILES

C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl

InChIKey

SGDBTWWWUNNDEQ-LBPRGKRZSA-N

XLogP

-0.5

Polar surface area

66.6 Ų

H-bond donors

2

H-bond acceptors

4

Formal charge

0

via PubChem

• Melphalan Flufenamide (Melflufen): First Approval.Drugs · 2021
• Melphalan: Recent insights on synthetic, analytical and medicinal aspects.European journal of medicinal chemistry · 2022
• Melphalan hydrochloride for the treatment of multiple myeloma.Expert opinion on pharmacotherapy · 2017
• Melphalan and its role in the management of patients with multiple myeloma.Expert review of anticancer therapy · 2007
• Melphalan.Report on carcinogens : carcinogen profiles · 2011

via PubMed