CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune response.
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CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune response.
T cells recognise CD1 using TCR αβ, γδ, or CD36 family members. T cells that are activated by CD1-antigen complexes are called CD1-restricted T cells. 10% of all αβ T lymphocytes in human peripheral blood are Cd1-restricted, out of which, the most abundant are the T cells specific for CD1c.
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