膜侵襲複合体
Sign in to saveAlso known as GO:0005579, terminal complement complex, MAC, TCC, Complement membrane attack complex
protein complex produced by components of the complement cascade inserted into a target cell membrane and forming a pore
Research
4,291 papers- Soluble Membrane Attack Complex: Biochemistry and Immunobiology.Frontiers in immunology · 2020
- Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets.The American journal of pathology · 2020
- The membrane attack complex as an inflammatory trigger.Immunobiology · 2016
- Structural basis for membrane attack complex inhibition by CD59.Nature communications · 2023
- Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys.Frontiers in immunology · 2020
via PubMed
Article · 日本語
膜侵襲複合体（まくしんしゅうふくごうたい、英:Membrane-Attack Complex :MAC）または終末補体複合体（しゅうまつほたいふくごうたい）、細胞膜傷害性複合体（さいぼうまくしょうがいせいふくごうたい）は、蛋白質から成る複合体。ふつう宿主の補体系の活性化により病原体の細胞膜表面、特にC3活性化部位の付近に形成され、の細胞膜に膜貫通孔を導くことで脂質二重膜を破壊し、それらを溶菌や細胞死に至らせる免疫系の作用因子（エフェクター）として働く。
Abstract from DBpedia / Wikipedia · CC BY-SA