補體系統膜攻擊複合物
Sign in to saveAlso known as GO:0005579, terminal complement complex, MAC, TCC, Complement membrane attack complex
protein complex produced by components of the complement cascade inserted into a target cell membrane and forming a pore
Research
4,291 papers- Soluble Membrane Attack Complex: Biochemistry and Immunobiology.Frontiers in immunology · 2020
- Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets.The American journal of pathology · 2020
- The membrane attack complex as an inflammatory trigger.Immunobiology · 2016
- Structural basis for membrane attack complex inhibition by CD59.Nature communications · 2023
- Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys.Frontiers in immunology · 2020
via PubMed
Article · 中文
膜攻擊複合物（MAC），是一種通常生成於致病細菌表面的結構。人體補體系統的替代補體途徑、經典補體途徑、凝集素途徑均可產生這種複合物。該複合物是免疫系統的效應蛋白之一，它可以在靶細胞的細胞膜上形成能破壞後者雙層磷脂質的穿膜通路，從而使得靶細胞裂解死亡。 有多種蛋白質參與膜攻擊複合物的組裝。具有高活性的C5b會與C6連接形成C5b-6複合體，隨後，C5b還會與C7連接形成C5b-6-7複合體。C5b-6-7複合物又會與由α、β、γ三條鍊構成的C8結合，形成C5b-6-7-8配合體。後者又會與C9結合，並作為C9聚合的催化劑。 具有活性的膜攻擊複合物的亞基組成為C5b-C6-C7-C8-C9{n}。
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