meropenem/vaborbactam
Sign in to saveAlso known as meropenem / vaborbactam, Vabomere
Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a combination medication used to treat complicated urinary tract infections, complicated abdominal infections, and hospital-acquired pneumonia. It contains meropenem, a beta-lactam antibiotic; and vaborbactam, a beta-lactamase inhibitor. It is given by injection into a vein.
Medication
- Brand names
- Vabomere
- Drug class
- Carbapenems
- Active ingredients
- vaborbactam, meropenem, meropenem / vaborbactam
- Dosage form
- Injection
Clinical Trials
10 registered- PHASE1COMPLETEDEvaluate Effects of Meropenem-Vaborbactam on QT/QTc in Healthy VolunteersRempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.) · NCT03564158
- PHASE1COMPLETEDThe Safety and Pharmacokinetics of Carbavance™ (RPX2014/RPX7009) in Subjects With Renal InsufficiencyRempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company) · NCT02020434
- PHASE3WITHDRAWNA Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial PneumoniaMelinta Therapeutics, Inc. · NCT03006679
- PHASE3COMPLETEDEfficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and APMelinta Therapeutics, Inc. · NCT02166476
- PHASE3COMPLETEDEfficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in AdultsRempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.) · NCT02168946
- COMPLETEDUse of New Antibiotics in SwedenUppsala University · NCT05048693
~4 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Side effects
- Antimicrobial activity
- History
- Research
- References
Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a combination medication used to treat complicated urinary tract infections, complicated abdominal infections, and hospital-acquired pneumonia. It contains meropenem, a beta-lactam antibiotic; and vaborbactam, a beta-lactamase inhibitor. It is given by injection into a vein.
Common side effects include headache, inflammation at the site of injection, nausea, diarrhea, liver inflammation, and low blood potassium. Severe side effects may include anaphylaxis, seizures, and Clostridioides difficile-associated diarrhea. It is unclear if use during pregnancy is safe. Meropenem works by blocking the construction of the bacterial cell wall while vaborbactam blocks the breakdown of meropenem by some beta-lactamases.
Excerpted from Wikipedia’s “meropenem/vaborbactam” article, available under the CC BY-SA 4.0 licence.