Structure via PubChem · Public domain (PubChem)
metaclazepam
Sign in to saveMetaclazepam (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam. It has an active metabolite N-desmethylmetaclazepam, which is the main metabolite of metaclazepam. There is no significant difference in metabolism between younger and older individuals.
Chemical data
- Formula
- C18H18BrClN2O
- Molecular weight
- 393.7 g/mol
- IUPAC name
- 7-bromo-5-(2-chlorophenyl)-2-(methoxymethyl)-1-methyl-2,3-dihydro-1,4-benzodiazepine
- SMILES
- CN1C(CN=C(C2=C1C=CC(=C2)Br)C3=CC=CC=C3Cl)COC
- InChIKey
- WABYCCJHARSRBH-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 24.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 392.029
Show 3 more facts
- chemical formula
- C₁₈H₁₈BrClN₂O
- canonical SMILES
- CN1C(CN=C(C2=C1C=CC(=C2)Br)C3=CC=CC=C3Cl)COC
- Commons category
- Metaclazepam
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Metaclazepam (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam. It has an active metabolite N-desmethylmetaclazepam, which is the main metabolite of metaclazepam. There is no significant difference in metabolism between younger and older individuals.
Metaclazepam is slightly more effective as an anxiolytic than bromazepam, or diazepam, with a 15 mg dose of metaclazepam equivalent to 4 mg of bromazepam. Metaclazepam can interact with alcohol producing additive sedative-hypnotic effects. Fatigue is a common side effect from metaclazepam at high doses. Small amounts of metaclazepam as well as its metabolites enter into human breast milk.
Excerpted from Wikipedia’s “metaclazepam” article, available under the CC BY-SA 4.0 licence.
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