methylprednisolone
Sign in to saveMethylprednisolone, sold under the brand name Medrol among others, is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. It is either used at low doses for chronic illnesses or used at high doses during acute flares. Methylprednisolone and its derivatives can be administered orally or parenterally.
Key facts
- Drug.pregnancy_AU
- A
- Drug.verifiedrevid
- 4771699945
- Drug.image
- Methylprednisolone.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Methylprednisolone.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 215
- Drug.tradename
- Medrol, others
- Drug.MedlinePlus
- a682795
- Drug.DailyMedID
- Methylprednisolone
- Drug.routes_of_administration
- By mouth, intramuscular, intra-articular, intravenous
- Drug.class
- Corticosteroid
- Drug.ATC_prefix
- D07
- Drug.ATC_suffix
- AA01
- Drug.ATC_supplemental
- , , , , , ,
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Research
33,874 papers- Methylprednisolone anaphylaxis.The American journal of emergency medicine · 1999
- Methylprednisolone suleptanate Pharmacia Corp.Current opinion in investigational drugs (London, England : 2000) · 2000
- Methylprednisolone.The Veterinary record · 1984
- Methylprednisolone treatment in multiple sclerosis: effect of treatment, pharmacokinetics, future.Multiple sclerosis (Houndmills, Basingstoke, England) · 1996
- Dangers from methylprednisolone acetate therapy by intraspinal injection.Archives of neurology · 1988
via PubMed
Article
38 sectionsContents
- Medical uses
- Asthma
- Rheumatic diseases
- Primary or secondary adrenocortical insufficiency
- Labeled indications
- Oral methylprednisolone
- Parenteral methylprednisolone
- Off-label indications
- Available forms
- Contraindications
- Adverse effects
- Central nervous system
- Metabolic and endocrine
- Infections
- Musculoskeletal
- Exhaustive list
- Withdrawal
- Drug interactions
- Enzyme inducers
- Cytochrome P450 (CYP) 3A4 inhibitors
- Oral contraceptives
- P-glycoprotein inhibitors
- Ciclosporin, tacrolimus, sirolimus (Rapamycin)
- Cox1 inhibitors
- Anticoagulants
- Pharmacology
- Signal transduction
- Genomic signaling
- Post-transcriptional modifications
- Non-genomic signaling
- The HPA
- Pharmacokinetics
- Physical properties
- Chemistry
- Synthesis
- History
- Research
- References
Methylprednisolone, sold under the brand name Medrol among others, is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. It is either used at low doses for chronic illnesses or used at high doses during acute flares. Methylprednisolone and its derivatives can be administered orally or parenterally.
Regardless of the route of administration, methylprednisolone integrates systemically as exhibited by its effectiveness to quickly reduce inflammation during acute flares. It is associated with many adverse reactions that require tapering off the drug as soon as the disease is under control. Serious side effects include iatrogenic Cushing's syndrome, hypertension, osteoporosis, diabetes, infection, psychosis, and skin atrophy.