Structure via PubChem · Public domain (PubChem)
cortivazol
Sign in to saveCortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid.
In the Vinony graph
Vinony's link graph records 272 inbound references to cortivazol, and connects out to mometasone furoate, fludrocortisone and ulipristal acetate.
Vinony files it under Acetate esters, Chemical pages without DrugBank identifier and Corticosteroid esters.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C32H38N2O5
- Molecular weight
- 530.7 g/mol
- IUPAC name
- [2-[(1S,2R,13S,14S,16R,17R,18S,20S)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxoethyl] acetate
- SMILES
- C[C@@H]1C[C@H]2[C@@H]3C=C(C4=CC5=C(C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)C)C=NN5C6=CC=CC=C6)C
- InChIKey
- RKHQGWMMUURILY-UHRZLXHJSA-N
- XLogP
- 3.9
- Polar surface area
- 102 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- pain
via ChEMBL · EBI
Research
70 papers- Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.The Journal of steroid biochemistry and molecular biology · 1991
- Cortivazol increases glucocorticoid receptor expression and inhibits growth of hamster pancreatic cancer (H2T) in vivo.Pancreas · 1993
- [3H]cortivazol: a unique high affinity ligand for the glucocorticoid receptor.Endocrinology · 1985
- Four cases of coccygeal disk calcification after cortivazol injection.Joint bone spine · 2009
- The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.Molecular endocrinology (Baltimore, Md.) · 2005
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 530.278
- Has use
- medication
Show 4 more facts
- chemical formula
- C₃₂H₃₈N₂O₅
- canonical SMILES
- CC1CC2C3C=C(C4=CC5=C(CC4(C3C(CC2(C1(C(=O)COC(=O)C)O)C)O)C)C=NN5C6=CC=CC=C6)C
- isomeric SMILES
- C[C@@H]1C[C@H]2[C@@H]3C=C(C4=CC5=C(C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)C)C=NN5C6=CC=CC=C6)C
- subject has role
- anti-inflammatory agent
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Cortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid.
It is sometimes abbreviated "CVZ".
Excerpted from Wikipedia’s “cortivazol” article, available under the CC BY-SA 4.0 licence.
Available in 6 languages
via Wikidata sitelinks · CC0