Structure via PubChem · Public domain (PubChem)
cortivazol
Sign in to saveCortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid.
Chemical data
- Formula
- C32H38N2O5
- Molecular weight
- 530.7 g/mol
- IUPAC name
- [2-[(1S,2R,13S,14S,16R,17R,18S,20S)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxoethyl] acetate
- SMILES
- C[C@@H]1C[C@H]2[C@@H]3C=C(C4=CC5=C(C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)C)C=NN5C6=CC=CC=C6)C
- InChIKey
- RKHQGWMMUURILY-UHRZLXHJSA-N
- XLogP
- 3.9
- Polar surface area
- 102 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- pain
via ChEMBL · EBI
Research
70 papers- Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.The Journal of steroid biochemistry and molecular biology · 1991
- Cortivazol increases glucocorticoid receptor expression and inhibits growth of hamster pancreatic cancer (H2T) in vivo.Pancreas · 1993
- [3H]cortivazol: a unique high affinity ligand for the glucocorticoid receptor.Endocrinology · 1985
- Four cases of coccygeal disk calcification after cortivazol injection.Joint bone spine · 2009
- The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.Molecular endocrinology (Baltimore, Md.) · 2005
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 530.278
- Has use
- medication
Show 4 more facts
- chemical formula
- C₃₂H₃₈N₂O₅
- canonical SMILES
- CC1CC2C3C=C(C4=CC5=C(CC4(C3C(CC2(C1(C(=O)COC(=O)C)O)C)O)C)C=NN5C6=CC=CC=C6)C
- isomeric SMILES
- C[C@@H]1C[C@H]2[C@@H]3C=C(C4=CC5=C(C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)C)C=NN5C6=CC=CC=C6)C
- subject has role
- anti-inflammatory agent
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Cortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid.
It is sometimes abbreviated "CVZ".
Excerpted from Wikipedia’s “cortivazol” article, available under the CC BY-SA 4.0 licence.
Available in 6 languages
via Wikidata sitelinks · CC0